Molecular Mechanisms and Immunomodulatory Effects of Platinum Analogs on Some Genes and as Anticancer Drugs: Review Article

Authors

Dalia Abdalkader Shakur

Article Type

Article

Abstract

Platinum analogs includes cisplatin, oxaliplatin and carboplatin. Cisplatin is a chemotherapeutic drugwith excellent success in the management of human malignancies. Molecular mechanism of actionrelated to its capacity to crosslink of DNA purine bases; also, by interfere with DNA repair, leading toDNA break, and consequently lead to apoptosis in cancer cells. Cisplatin also found to haveimmunomodulatory properties besides its cytotoxic effect.

Keywords

Cisplatin, Cancer, Molecular and Immunomodulatory effects, Genes repair

Recommended Citation

Shakur, Dalia Abdalkader (2025) "Molecular Mechanisms and Immunomodulatory Effects of Platinum Analogs on Some Genes and as Anticancer Drugs: Review Article," Muthanna Medical Journal: Vol. 7: Iss. 1, Article 1.
Available at: https://muthmj.researchcommons.org/journal/vol7/iss1/1

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