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Article Type

Article

Abstract

Gestational Diabetes Mellitus (GDM) is an important cause of perinatal mortality and morbidity, the abnormalities of the metabolic syndrome and a high risk health profile are more frequent among women with previous GDM, and the metabolic syndrome is characterized by several risk factors, including central obesity, hypertension, insulin resistance and dyslipidemia. The purpose of this study: was to compare change in insulin sensitivity and lipid profiles in Sudanese women with GDM. A case control study was performed at Wed Medani, Teaching Hospital of Obstetrics and Gynecology, Gezira State, central Sudan, included 200 pregnant women between 24 - 28 weeks gestation, classified into two main groups using oral glucose tolerance test: Normal Glucose Tolerance NGT (n= 100) and GDM (n= 100). Plasma were used for determination of fasting blood glucose (FBG), fasting insulin (FI). Serum was used for Total cholesterol (TC), Triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and High-density lipoprotein cholesterol (HDL-C). Insulin resistance (IR) markers were calculated including glucose/insulin ratio (G/I), fasting insulin resistance index (FIRI) and homeostasis model assessment of insulin resistance (HOMA-IR), Log HOMA-IR, Among 200 women, 100 (50%) developed GDM had higher body mass index (BMI; 30.118 vs. 28.604 kg/m2 p= 0.046) and age (29.23 vs. 27.360 years p= 0.010), In comparison to 100(50%) NGT. women with GDM characterized by a higher fasting blood sugar was (102.370 vs. 81.920 mg/dl p< 0.000) and had significantly higher Fasting TC(202.630 vs. 182.850 p= -0. 001) and TG(179.530 vs. 159.690 mg/dl P=0 .024)and LDL-C(143.750 vs 130.3200P mg/dl p= 0. 029), while HDL-C and fasting insulin level did not show significant variations between the two groups (p= 0. 417and p =0.359 respectively), insulin resistance (IR) markers were show significant differences (G/I 0.78 vs. 0.56 p= 0.000. FIRI 2.214vs1.61 p= 0.001 HOMA-IR 2.467 vs 1.792 p= 0.001). Correlation analysis showed that Pregnancies complicated with GDM, HOMA-IR was significantly correlated with FBG (r= 0.317, p= 0.001), BMI (r= 0.429, p= 0.000), TG(r= 0.244, p= 0.015) and LDL(r= 0.295, p= 0.013), while it was no significantly correlated with TC (r= 0.194, p= 0.05) and HDL (r=-0.056, p = 0.578). Our findings provide evidence of GDM as a condition primarily of IR and it also provides evidence of the association of dyslipidemia with IR.

Keywords

Gestational diabetes mellitus, Insulin resistance, Lipid, Sudanese women

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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